教育工作经历

2022年04月－现今：新葡萄3522登录网页版 教授 博士生导师

2020年10月－2022年03月：西北工业大学教授/前沿交叉研究中心主任

2019年04月－2020年10月：新加坡纳米生物国家实验室 课题组长/资深研究员

2014年07月－2019年03月：新加坡生物工程和纳米技术研究院课题组长/资深研究员

2006年07月－2014年06月：新加坡国立大学化学系助理教授及国立大学药物化学平台的核心成员

2002年03月－2006年06月：美国斯克利普斯研究所博士后。师从美国科学院及医学院双院士 Peter G. Schultz 教授

2002年02月：美国纽约州立大学布法罗分校理学博士学位, 师从 Gong Bing 教授

1996年07月：中国科学技术大学理学学士

教学简介

为本科生和研究生讲授 Organic Chemistry for Engineers, Advanced Organic Synthesis and Spectroscopy, Topics in Supramolecular Chemistry 等课程

科研简介

研究方向为生物有机功能超分子化学 (人工离子/水/DNA/质子通道)及在海水淡化，抗癌新药和第三代基因测序技术开发中的应用）。在国际主流化学期刊上以主要通讯作者发表SCI收录论文80多篇，包括1篇Nat. Nanotech.,11篇 J. Am. Chem. Soc., 9篇Angew. Chem. Int. Ed.和1篇Nat. Commun.，H-index = 46。

社会兼职

无

科研项目

(1) S$3,498,800 from National Research Foundation Competitive Research Programme; Project title: Synthetic water channel-based biomimetic hybrid membranes for water desalination; expiry date: 30/09/2019

(2) $108,000 from The Faculty Research Committee (FRC) of NUS; Project title: Conformationally Switchable Fluorescent Oligophenol Foldamers as Amine/Ion Sensors; expiry date: 31/01/2015

(3) $150,000 from The Faculty Research Committee (FRC) of NUS; Project title: Water-binding aquafoldamers as synthetic water channels for water reuse and desalination; expiry date: 31/05/2014

(4) $68,000 from The Faculty Research Committee (FRC) of NUS; Project title: Novel Biosensors for sensitive and specific protein detection by the naked eyes; expiry date: 31/08/2013

(5) $25,000 from Cross-Faculty Research Grant of NUS; Project title: DNA‐based Nanosensors for Sensitive Detection and Rapid Monitoring of Environmental Contaminants; expiry date: 31/03/2012

(6) $155,000 from The Faculty Research Committee (FRC) of NUS; Project title: Tuning the Alkali Metal-Binding Affinities of Helical Oligoaromatic Foldamers; Expiry date: 30/06/2012

(7) $480,000 from Biomedical Research Council (BMRC); Project title: Synthesis and evaluation of planar pentavalent ligands targeting dimeric interface of serum amyloid P component for the therapeutic elimination of Alzheimer's disease; expiry date: 31/12/2011

(8) $179,987 from The Faculty Research Committee (FRC) of NUS; Project title: Synthetic Ion Channels with Tunable Interior Properties Derived from the Attachment of Circular Ion-Binding Units to A Linear, Rigid Scaffold; expiry date: 31/03/2011

(9) $179,960 from The Faculty Research Committee (FRC) of NUS; Project title: Chemical Models toward Protein β-Sheet/Turn Structures and Their Biological Implications; Expiry date: 31/08/2008

代表性论文

1.Shen, J.; R, D.; Li, Z.; Oh, H.; Behera, H.; Joshi, H.; Kumar, M.; Aksimentiev, A.; Zeng, H. Q.* Sulfur-Containing Foldamer-Based Artificial Lithium Channels. Angew. Chem. Int. Ed. 2023, 62, e202305623

2. Shen, J.; Gu, Y.; Ke, L.; Zhang, Q.; Cao, Y.; Lin, Y.; Wu, Z.; Wu, C.; Mu, Y.; Wu, Y.-L.; Ren, C.*; Zeng, H. Q.* Cholesterol-Stabilized Membrane-Active Nanopores with Anticancer Activities. Nat. Commun. 2022, 13, 5985

3. Shen, J.; Ye, R.; Liu, Z; Zeng, H. Q.* Hybrid Pyridine-Pyridone Foldamer Channels as M2-Like Artificial Proton Channels. Angew. Chem. Int. Ed. 2022, 61, e202200259

4. Shen, J.; Ren, C. L.; Zeng, H. Q.* Membrane-Active Molecular Machines. Acc. Chem. Res. 2022, 55, 1148–1159

5. Shen, J.; Roy, A.; Joshi, H.; Samineni, L.; Ye, R. J.; Tu, Y.-M.; Song, W.; Skiles, M.; Kumar, M.; Aksimentiev, A.; Zeng, H. Q.* Fluorofoldamer-Based Salt- and Proton-Rejecting Artificial Water Channels for Ultrafast Water Transport. Nano Lett. 2022, 22, 4831–4838

6. Roy, A.; Shen, J.; Joshi, H.; Song, W.; Tu, Y.-M.; Chowdhury, R.; Ye, R. J.; Li, N.; Ren, C.; Kumar, M.; Aksimentiev, A.; Zeng, H. Q.,* Foldamer-Based Ultrapermeable and Highly Selective Artificial Water Channels that Exclude Protons. Nat. Nanotech. 2021, 16, 911-917

7. Shen, J.; Ye, R. J.; Zeng, H. Q.,* Crystal Packing-Guided Construction of Hetero-Oligomeric Peptidic Ensembles as Synthetic 3-in-1 Transporters. Angew. Chem. Int. Ed. 2021, 60, 12924-12930 (Hot paper)

8. Zhang, H.; Ye, R. J.; Mu, Y. G.; Li, T.; Zeng, H. Q.,* Small Molecule-Based Highly Active and Selective K+ Transporters with Potent Anticancer Activities. Nano Lett. 2021, 21, 1384–1391

9. Shen, J.; Han, J. J. Y.; Ye, R. J.; Zeng, H. Q.,* Molecular rotors as a class of generally highly active ion transporters. Sci. China Chem. 2021, 64, 2154-2160

10. Li, N.; Shen, J.; Ang, G. K.; Ye, R. J.; Zeng, H. Q.,* Molecular Tetrahedrons as Selective and Efficient Ion Transporters via a Two-Station Swing-Relay Mechanism. CCS Chem. 2020, 2, 2269-2279

11. Li, N.; Chen, F.; Shen, J.; Zhang, H.; Wang, T.; Ye, R. J.; Li, T.; Loh, T.P.; Yang, Y.Y.; Zeng, H. Q.,* Buckyball-Based Spherical Display of Crown Ethers for De Novo Custom Design of Ion Transport Selectivity. J. Am. Chem. Soc. 2020, 142, 21082-21090

12. Shen, J.; Ye, R. J.; Romanies, A.; Lin, Y.; Roy, A.; Chen, F.; Ren, C. L., Liu, Z.; Zeng, H. Q.,* Aquafoldmer-Based Aquaporin-like Synthetic Water Channel. J. Am. Chem. Soc. 2020, 142, 10050-10058

13. Shen, J.; Fan, J.; Ye, R. J.; Li, N.; Mu, Y.; Zeng, H. Q.,* Polypyridine-Based Helical Amide Foldamer Channels: Rapid Transport of Water and Protons with High Ion Rejection. Angew. Chem. Int. Ed. 2020, 59, 13328-13334

14. Roy, A.; Joshi, H.; Ye, R. J.; Shen, J.; Chen, F.; Aksimentiev, A.*; Zeng, H. Q.,* Polyhydrazide-Based Organic Nanotubes as Efficient and Selective Artificial Iodide Channels. Angew. Chem. Int. Ed. 2020, 59, 4806-4813

15. Chen, F.; Shen, J.; Li, N.; Roy, A.; Ye, R. J.; Ren, C. L.; Zeng, H. Q.,* Pyridine/Oxadiazole-Based Helical Foldamer Ion Channels with Exceptionally High K+/Na+ Selectivity. Angew. Chem. Int. Ed. 2020, 59, 1440-1444

16. Ye, R. J.; Ren, C. L.; Shen, J.; Li, N.; Chen, F.; Roy, A.; Zeng, H. Q.,* Molecular Ion Fishers as Highly Active and Exceptionally Selective K+ Transporters. J. Am. Chem. Soc. 2019, 141, 9788-9792

17. Ren, C. L.; Chen, F.; Ye, R. J.; Ong, Y. S.; Lu, H. F.; Lee, S. S.; Ying, J. Y.-R.; Zeng, H. Q.,* Molecular swings as highly active ion transporters. Angew. Chem. Int. Ed. 2019, 58, 8034-8038 (Hot Paper)

18. Ren, C. L.; Zeng, F.; Shen, J.; Chen, F.; Roy, A.; Zhou, S.; Ren, H.; Zeng, H. Q.,* Pore-Forming Monopeptides as Exceptionally Active Anion Channels. J. Am. Chem. Soc. 2018, 140, 8817–8826

19. Ren, C. L.; Ding, Z.; Roy, A.; Shen, J.; Zhou, S. Y.; Chen, F.; Li, S.; Ren, H. S..; Yang, Y. Y.; Zeng, H. Q.,* A halogen bond-mediated highly selective and active artificial chloride channel with high anticancer activity. Chem. Sci. 2018, 9, 4044-4051 (Front Cover)

20. Ren, C. L.; Shen, J.; Zeng, H. Q.,* Combinatorial evolution of fast-conducting highly selective K+-channels via modularly tunable directional assembly of crown ethers J. Am. Chem. Soc. 2017, 139, 12338–12341

21. Shen, J.; Ren, C. L.; Zeng, H. Q.,* Surprisingly high selectivity and high affinity in mercury recognition by H-bonded cavity-containing aromatic foldarands. J. Am. Chem. Soc. 2017, 139, 5387–5396

22. Ren, C. L.; Shen, J.; Chen, F.; Zeng, H. Q.,* Rapid Room-Temperature Gelation of Crude Oils by a Wetted Powder Gelator. Angew. Chem. Int. Ed. 2017, 56, 3847-3851

23. Lee, K. H.; Zeng, H. Q.,* Aptamer-Based ELISA Assay for Highly Specific and Sensitive Detection of Zika NS1 Protein. Anal. Chem. 2017, 89, 12743-12748

24. Huo, Y. P.; Zeng, H. Q.,* “Sticky”-Ends-Guided Creation of Functional Hollow Nanopores for Guest Encapsulation and Water Transport Acc. Chem. Res. 2016, 49, 922–930

25. Liu, Y.; Shen, J.; Sun, C.; Zeng, H. Q.,* Intramolecularly Hydrogen-Bonded Aromatic Pentamers as Modularly Tunable Macrocyclic Receptors for Selective Recognition of Metal Ions. J. Am. Chem. Soc. 2015, 137, 12055–12063

26. Zhao, H. Q.; Sheng, S.; Hong, Y. H.; Zeng, H. Q.,* Proton Gradient-Induced Water Transport Mediated by Water Wires inside Narrow Aquapores of Aquafoldamer Molecules J. Am. Chem. Soc. 2014, 136, 14270-14276

27. Fu, H. L.; Liu, Y.; Zeng, H. Q.,* Shape-persistent H-bonded macrocyclic aromatic pentamers. Chem. Commun. 2013, 49, 4127 (Invited Feature Article for 2013 ChemComm Emerging Investigators Themed Issue)

28. Zhao, H. Q.; Ong, W. Q.; Zhou, F.; Fang, X.; Chen, X. Y.; Li, S. F. Y.; Su, H. B.; Cho, N.-J.; Zeng, H. Q.,* Chiral crystallization of aromatic helical foldamers via complementarities in shape and end functionalities. Chem. Sci. 2012, 3, 2042.

29. Liu, Y.; Qin, B.; Zeng, H. Q.,* POCl3-mediated H-bonding-directed one-pot synthesis of macrocyclic pentamers, strained hexamers and highly strained heptamers. Sci. China Chem. 2012, 55, 55 (front cover).

30. Ren, C. L.; Maurizot, V.; Zhao, H. Q.; Shen, J.; Zhou, F.; Ong, W. Q.; Du, Z. Y.; Zhang, K.; Su, H. B.; Zeng, H. Q.,* Fivefold-symmetric macrocyclic aromatic pentamers: High affinity cation recognition, ion-pair induced columnar stacking and nanofibrillation. J. Am. Chem. Soc. 2011, 133, 13930.

31. Ren, C. L.; Zhou, F.; Qin, B.; Ye, R. J.; Shen, S.; Su, H. B.; Zeng, H. Q.,* Crystallographic realization of the mathematically predicted densest “All Pentamer” packing lattice by C5-symmetric “sticky” fluoropentamers. Angew. Chem. Int. Ed. 2011, 50, 10612.

32. Yan, Y.; Qin, B.; Ren, C. L.; Chen, X. Y.; Yip, Y. K.; Ye, R. J.; Zhang, D. W.; Su, H. B.; Zeng, H. Q.,* Synthesis, structural investigations, hydrogen−deuterium exchange studies, and molecular modeling of conformationally stablilized aromatic oligoamides. J. Am. Chem. Soc. 2010, 132, 5869.

33. Qin, B.; Ren, C. L.; Ye, R. J.; Sun, C.; Chiad, K.; Chen, X. Y.; Li, Z.; Xue, F.; Su, H. B.; Chass, G. A.; Zeng, H. Q.,* Persistently folded circular aromatic amide pentamers containing modularly tunable cation-binding cavities with high ion selectivity. J. Am. Chem. Soc. 2010, 132, 9564.

获奖情况

2023年福建省海外引进A类人才

其他

2011年10月入选Nature Chemistry的Sceptical Chymist

2013年入选2013年度Chemical Communications的Emerging Investigators”

2021年6月入选国际芳香折叠体六人指导委员会

2021年8月入选中国化学会旗帜期刊（CCS Chemistry）Author Spotlight

2022年2月被Angew. Chem. Int. Ed.评为2021年度Top 10%优秀审稿人。

招聘信息

1.科研助理1名（化学、化学生物学、药学、材料学等相关专业背景的硕士）。

2.专任教师3-5名：（副）研究员、（副）教授、闽江学者、海外优青。以一作或通讯作者发表“三类高质量”论文5篇（其中，JACS/Angew 或同等期刊至少2篇）。

3.常年招收具有化学、化学生物学、药学、材料学等相关专业背景的硕士、博士、博士后。

      有意向者请发送简历至邮箱：hqzeng@fzu.edu.cn